Longitudinal multiomic signatures of ARDS and sepsis inflammatory phenotypes identify pathways associated with mortality.

doi:10.1172/JCI196290

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Article

Longitudinal multiomic signatures of ARDS and sepsis inflammatory phenotypes identify pathways associated with mortality.

The Journal of clinical investigation - 2 Feb 2026

Alipanah-Lechner Narges, Neyton Lucile, Sinha Pratik, Leroux Carolyn, Bardillon Kim, Carrillo Sidney A, Chak Suzanna, Chao Olivia, Hariharan Taarini, Hendrickson Carolyn, Kangelaris Kirsten, Langelier Charles R, Lee Deanna, Lin Chelsea, Liu Kathleen, Magee Liam, Ringor Angelika, Sarma Aartik, Schmiege Emma, Spottiswoode Natasha, Sullivan Kathryn, Weingart Melanie F, Willmore Andrew, Zhuo Hanjing, Rogers Angela J, Stringer Kathleen A, Matthay Michael A, Calfee Carolyn S

Abstract excerpt

BACKGROUNDCritically ill patients with acute respiratory distress syndrome (ARDS) and sepsis exhibit distinct inflammatory phenotypes with divergent clinical outcomes, but the underlying molecular mechanisms remain poorly understood. These phenotypes, derived from clinical data and protein biomarkers, were associated with metabolic differences in a pilot study.METHODSWe performed integrative multiomics analysis...

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PMID: 41329523
DOI: 10.1172/JCI196290
PMCID: PMC12867137

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