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Article

sGC agonist BAY1021189 promotes thoracic aortic dissection formation by accelerating vascular smooth muscle cell phenotype switch.

European journal of pharmacology - 5 Aug 2023

Jiang Hongcheng, Jiang Yue, Qu Yunkun, Lv Jiagao, Zeng Hesong

Abstract excerpt

Thoracic aortic dissection (TAD) is common but lethal cardiovascular disease with high mortality. This study aimed to expound whether and how sGC-PRKG1 signaling pathway might promote the formation of TAD. Our work identified two modules with high relevance to TAD using WGCNA method. Combined with previous studies, we focused on the participation of endothelial NOS (eNOS) in the progression of TAD. Through...

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Identifiers

PMID: 37244376
DOI: 10.1016/j.ejphar.2023.175789

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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