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Article

FSTL1 protects against acute aortic dissection by suppressing vascular smooth muscle cell phenotypic switching and degradation of the extracellular matrix.

Journal of molecular and cellular cardiology - 1 Jan 2025

Li Jun-Ping, He Wan-Bing, Xu Shu-Wan, Liu Juan-Zhang, Huang Zhao-Qi, Li Chang-Ping, Huang Chun-Ling, Mai Pei-Biao, Geng Deng-Feng, Qiu Xiao-Fu, Liu Zhao-Yu, Zhang Kun, Zhou Shu-Xian

Abstract excerpt

Acute aortic dissection (AAD) is a life-threatening cardiovascular emergency, which is closely related to the vascular smooth muscle cells (VSMCs) phenotypic switching and extracellular matrix (ECM) degradation. Previous studies have found that the secreted extracellular glycoprotein Follistatin-like 1 (FSTL1) is demonstrated as a protective factor for cardiovascular diseases. However, the role of FSTL1 in AAD...

Topics

Follistatin-Related Proteins
Animals
Aortic Dissection
Muscle, Smooth, Vascular
Extracellular Matrix
Humans
Mice
Myocytes, Smooth Muscle
Male
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Disease Models, Animal

Mice, Inbred C57BL

Aminopropionitrile

Phosphorylation

Matrix Metalloproteinase 2

Source

Identifiers

PMID: 39631359
DOI: 10.1016/j.yjmcc.2024.11.008

Genes

FSTL1
MMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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