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Article

Notch1 gene promoter methylation promotes phenotypic transformation and functional alteration of VSMCs to regulate acute type A aortic dissection.

Biochimica et biophysica acta. General subjects - 1 Jun 2026

Liu Hui, Yuan Zhaoshun, Zhang Zhiyuan, Tang Liang, Shen Kangjun

Abstract excerpt

Acute type A aortic dissection (ATAAD) is a life-threatening cardiovascular emergency. A key driver of disease progression is dysfunction of vascular smooth muscle cells (VSMCs), whose loss of contractile phenotype and increased matrix degradation contribute to aortic wall weakening. Aberrant DNA methylation patterns have been observed in thoracic aortic disease and linked to VSMCs dysfunction and extracellular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Matrix Metalloproteinase 2

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Share to Muscle, Smooth, Vascular

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Source

Identifiers

PMID: 41690418
DOI: 10.1016/j.bbagen.2026.130918

Genes

MMP2
MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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