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Article

Near-identical macromolecules spontaneously partition into concentric circles.

Nature - 1 Dec 2024

Gong Hao, Sakaguchi Yuriko, Suzuki Tsutomu, Yanagisawa Miho, Aida Takuzo

Abstract excerpt

Although separation is entropically unfavourable, it is often essential for our life1,2. The separation of very similar macromolecules such as deoxyribonucleic acids (DNAs) and their single nucleotide variants is difficult but holds great advantage for the progress of life science3. Here we report that a particular liquid-liquid phase separation (LLPS) at a solid-liquid interface led to the partitioning of DNAs...

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PMID: 39633194
DOI: 10.1038/s41586-024-08203-4

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