Article
Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutions.
Proceedings of the National Academy of Sciences of the United States of America - 12 Jul 2022
Kar Mrityunjoy, Dar Furqan, Welsh Timothy J, Vogel Laura T, Kühnemuth Ralf, Majumdar Anupa, Krainer Georg, Franzmann Titus M, Alberti Simon, Seidel Claus A M, Knowles Tuomas P J, Hyman Anthony A, Pappu Rohit V
Abstract excerpt
Macromolecular phase separation is thought to be one of the processes that drives the formation of membraneless biomolecular condensates in cells. The dynamics of phase separation are thought to follow the tenets of classical nucleation theory, and, therefore, subsaturated solutions should be devoid of clusters with more than a few molecules. We tested this prediction using in vitro biophysical studies to...
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