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Article

Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein.

Molecular cell - 7 Jul 2016

Pak Chi W, Kosno Martyna, Holehouse Alex S, Padrick Shae B, Mittal Anuradha, Ali Rustam, Yunus Ali A, Liu David R, Pappu Rohit V, Rosen Michael K

Abstract excerpt

Liquid-liquid phase separation, driven by collective interactions among multivalent and intrinsically disordered proteins, is thought to mediate the formation of membrane-less organelles in cells. Using parallel cellular and in vitro assays, we show that the Nephrin intracellular domain (NICD), a disordered protein, drives intracellular phase separation via complex coacervation, whereby the negatively charged...

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Identifiers

PMID: 27392146
DOI: 10.1016/j.molcel.2016.05.042
PMCID: PMC4973464

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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