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The need for Cre-loci controls in conditional mouse experiments: Mrp8-cre transgene predisposes mice to antibody-induced arthritis.

Genes and immunity - 1 Apr 2025

Xu Zhongwei, Romero-Castillo Laura, Moreno-Giró Àlex, Pandey Rajan Kumar, Holmdahl Rikard

Abstract excerpt

The Cre/loxP system is extensively utilized to pinpoint gene functions in specific cell types or developmental stages, typically without major disturbance to the host's genome. However, we found that the random insertion of the Mrp8-cre transgene significantly promotes the host's innate immune response. This effect is characterized by elevated susceptibility to cartilage antibody-induced arthritis, likely due to...

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Identifiers

PMID: 39632992
DOI: 10.1038/s41435-024-00313-3
PMCID: PMC12006020

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