Article
Cartilage-Specific Cre Recombinase Transgenes/Alleles in the Mouse.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2021
Kanakis Ioannis, Alhashmi Mohammad, Liu Ke, Keenan Craig, Ramos Mucci Lorenzo, Poulet Blandine, Bou-Gharios George
Abstract excerpt
Cartilage is a specialized skeletal tissue with a unique extracellular matrix elaborated by its resident cells, chondrocytes. The tissue presents in several forms, including growth plate and articular cartilage, wherein chondrocytes follow a differential differentiation program and have different fates. The induction of gene modifications in cartilage specifically relies on mouse transgenes and knockin alleles...
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