Article
Histopathologic and transcriptomic phenotypes of a conditional RANKL transgenic mouse thymus.
Cytokine - 1 Dec 2022
Szwarc Maria M, Hai Lan, Maurya Vineet K, Rajapakshe Kimal, Perera Dimuthu, Ittmann Michael M, Mo Qianxing, Lin Yong, Bettini Matthew L, Coarfa Cristian, Lydon John P
Abstract excerpt
Although conventional knockout and transgenic mouse models have significantly advanced our understanding of Receptor Activator of NF-κB Ligand (RANKL) signaling in intra-thymic crosstalk that establishes self-tolerance and later stages of lymphopoiesis, the unique advantages of conditional mouse transgenesis have yet to be explored. A main advantage of conditional transgenesis is the ability to express a...
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