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Alzheimer’s disease-specific transcriptomic and epigenomic changes in the tryptophan catabolic pathway

30 Nov 2024

Abstract excerpt

BACKGROUND: Neurodegenerative disorders, including Alzheimer's disease (AD), have been linked to alterations in tryptophan (TRP) metabolism. However, no studies to date have systematically explored changes in the TRP pathway at both transcriptional and epigenetic levels. This study aimed to investigate transcriptomic, DNA methylomic (5mC) and hydroxymethylomic (5hmC) changes within genes involved in the TRP and...

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PMID: 39616392
DOI: 10.1186/s13195-024-01623-4

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