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Alzheimer’s disease-associated (hydroxy)methylomic changes in the brain and blood

27 Nov 2019

Abstract excerpt

Abstract Background Late-onset Alzheimer’s disease (AD) is a complex multifactorial affliction, the pathogenesis of which is thought to involve gene-environment interactions that might be captured in the epigenome. The present study investigated epigenome-wide patterns of DNA methylation (5-methylcytosine, 5mC) and hydroxymethylation (5-hydroxymethylcytosine, 5hmC), as well as the abundance of unmodified cytosine...

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PMID: 31775875
DOI: 10.1186/s13148-019-0755-5

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