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Article

A conditional smoothened (smo) allele on an inbred C57BL/6J genetic background has a hypomorphic smo mutant phenotype.

Developmental biology - 1 Feb 2025

Houghtaling Scott, Gombart Sean K, Ho Tzu-Hua, Huang Grace, Beier David R

Abstract excerpt

We have introduced the floxed allele of Smoothened (Smo) carried by the mouse line Smotm2Amc into the C57BL/6J strain by serial backcross. Recapitulation of the Smo null phenotype was confirmed by deleting the allele using E2a-cre and intercrossing heterozygous Smo ± mice. No homozygous mutant embryos were identified at E9.5, suggesting the null phenotype is at least as severe as that observed on a mixed genetic...

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Identifiers

PMID: 39603584
DOI: 10.1016/j.ydbio.2024.11.010
PMCID: PMC11728190

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