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Article

Hypomorphic Smo mutant with inefficient ciliary enrichment disrupts the highest level of vertebrate Hedgehog response.

Developmental biology - 15 May 2018

Gigante Eduardo D, Long Alyssa Bushey, Ben-Ami Johanna, Caspary Tamara

Abstract excerpt

Smoothened (Smo) is the essential transducer of Sonic hedgehog (Shh) signaling, which regulates cell fate and proliferation during embryogenesis. We identified a novel mouse mutant, cabbie (cbb), and found that its cause is a missense mutation in Smo. We showed the Smocbb mutation is insensitive to the Shh agonist SAG, perhaps due to the disruption of SAG binding. We characterized Smocbb for defects in...

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Identifiers

PMID: 29571613
DOI: 10.1016/j.ydbio.2018.03.019
PMCID: PMC5903954

Genes

SAG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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