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Article

Generation of miR-141/200c conditional knockout mice from knockout-first, reporter-tagged parent and functional validation of the floxed allele.

Mammalian genome : official journal of the International Mammalian Genome Society - 3 Sept 2026

Yadav Sanjeev Kumar, Srivastava Rashmi, Cormier Mary-Katherine, Lowther Katie, Yee Siu-Pok, Verma Rajkumar

Abstract excerpt

MicroRNAs (miRNAs) of the miR-200 family-specifically miR-141 and miR-200c-regulate neurogenesis, differentiation, and epithelial-mesenchymal transitions in development. Dysregulation of these miRNAs is associated with several diseases including cancer and stroke. The Mirc13tm1Mtm/Mmjax mouse line, which targets the miR-141/200c cluster, was originally generated and described by Park et al. 2012 as a...

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Topics

Animals
MicroRNAs
Mice
Mice, Knockout
Genes, Reporter
Alleles

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Identifiers

PMID: 42693338
DOI: 10.1007/s00335-026-10271-y
PMCID: PMC13625085

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