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Article

A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway.

Cancer research - 15 Oct 2006

Mao Junhao, Ligon Keith L, Rakhlin Elena Y, Thayer Sarah P, Bronson Roderick T, Rowitch David, McMahon Andrew P

Abstract excerpt

We report a novel mouse model for the generation of sporadic tumors and show the efficiency of this approach by surveying Hedgehog (Hh)-related tumors. Up-regulation of the Hh pathway is achieved by conditionally regulated expression of an activated allele of Smoothened (R26-SmoM2) using either sporadic leakage or global postnatal induction of a ubiquitously expressed inducible Cre transgene (CAGGS-CreER)....

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Identifiers

PMID: 17047082
DOI: 10.1158/0008-5472.CAN-06-0657
PMCID: PMC3806052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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