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Article

Shb null allele is inherited with a transmission ratio distortion and causes reduced viability in utero.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Sept 2007

Kriz Vitezslav, Mares Jaroslav, Wentzel Parri, Funa Nina S, Calounova Gabriela, Zhang Xiao-Qun, Forsberg-Nilsson Karin, Forsberg Maud, Welsh Michael

Abstract excerpt

SHB is an Src homology 2 domain-containing adapter protein that has been found to be involved in numerous cellular responses. We have generated an Shb knockout mouse. No Shb-/- pups or embryos were obtained on the C57Bl6 background, indicating an early defect as a consequence of Shb- gene inactivation on this genetic background. Breeding heterozygotes for Shb gene inactivation (Shb+/-) on a mixed genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17676633
DOI: 10.1002/dvdy.21257

Genes

SHB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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