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Article

Early disruption of the CREB pathway drives dendritic morphological alterations in FTD/ALS cortical neurons

26 Nov 2024

Abstract excerpt

Synaptic loss and dendritic degeneration are common pathologies in several neurodegenerative diseases characterized by progressive cognitive and/or motor decline, such as Alzheimer's disease (AD) and frontotemporal dementia/amyotrophic lateral sclerosis (FTD/ALS). An essential regulator of neuronal health, the cAMP-dependent transcription factor CREB positively regulates synaptic growth, learning, and memory....

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PMID: 39589881
DOI: 10.1073/pnas.2406998121

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