Article

Caspase inhibition restores dopaminergic identity through the PKA–CREB–BDNF axis in Parkinson’s disease neurons

2025-09-04

Abstract excerpt

<title>Abstract</title> <p>The progressive loss of dopaminergic identity in midbrain neurons is a hallmark of Parkinson’s disease (PD), contributing to synaptic dysfunction and neurodegeneration. While a subset of PD cases is linked to genetic mutations, the majority are sporadic (sPD) and of unknown etiology. Current therapies offer only symptomatic relief and do not prevent neurodegeneration, underscoring the u...

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Literature Corpus work: 489591aa-9134-52c4-bc35-ddc63a4f55af
DOI: 10.21203/rs.3.rs-7289863/v1

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