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Article

Synaptic disruption and CREB‐regulated transcription are restored by K+ channel blockers in ALS

14 Jun 2021

Abstract excerpt

Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, which is still missing effective therapeutic strategies. Although manipulation of neuronal excitability has been tested in murine and human ALS models, it is still under debate whether neuronal activity might represent a valid target for efficient therapies. In this study, we exploited a combination of transcriptomics, proteomics,...

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PMID: 34125498
DOI: 10.15252/emmm.202013131

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