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TDP-43 dysfunction restricts dendritic complexity by inhibiting CREB activation and altering gene expression

11 May 2020

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two related neurodegenerative diseases that present with similar TDP-43 pathology in patient tissue. TDP-43 is an RNA-binding protein which forms aggregates in neurons of ALS and FTD patients as well as in a subset of patients diagnosed with other neurodegenerative diseases. Despite our understanding that TDP-43 is essential for many...

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PMID: 32393629
DOI: 10.1073/pnas.1917038117

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