Article

TDP-43 dysfunction restricts dendritic complexity by inhibiting CREB activation and altering gene expression

2019-12-13

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two related neurodegenerative diseases that present with similar TDP-43 pathology in patient tissue. TDP-43 is an RNA-binding protein and forms aggregates in neurons of ALS and FTD patients as well as in a subset of patients diagnosed with other neurodegenerative diseases. Despite our understanding that TDP-43 is essential for many aspects o...

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Literature Corpus work: f8c7b225-fe33-519b-9497-48c13f292764
DOI: 10.1101/2019.12.12.874735

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