Article

Preventing Jacob-induced transcriptional inactivation of CREB protects synapses from β-amyloid in Alzheimer’s Disease

2020-01-09

Abstract excerpt

Synaptic dysfunction caused by soluble β-Amyloid (Aβ) is a hallmark of the early stage of Alzheimer’s disease (AD) and is tightly linked to cognitive decline. Aβ induces by yet unknown mechanisms disruption of transcriptional activity of cAMP– responsive element-binding protein (CREB), a master regulator of cell survival and plasticity-related gene expression. Here, we report that Aβ elicits cytonuclear traffickin...

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Literature Corpus work: 14cda7cb-3459-5ad9-8f6f-8bfb100bf57a
DOI: 10.1101/2020.01.08.898304

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