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Article

Polygenic risk scores in the clinic: a systematic review of stakeholders' perspectives, attitudes, and experiences.

European journal of human genetics : EJHG - 1 Mar 2025

Andreoli Lara, Peeters Hilde, Van Steen Kristel, Dierickx Kris

Abstract excerpt

Polygenic Risk Scores (PRS) are statistical methods estimating part of an individual's genetic susceptibility to various disease phenotypes. Their potential clinical applications to enhance the prediction, prevention, and risk management of complex conditions motivate current research efforts worldwide. While a growing body of literature has highlighted the scientific and ethical limitations of PRS, the...

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PMID: 39580561
DOI: 10.1038/s41431-024-01747-z
PMCID: PMC11894113

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