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Article

Challenges in clinical translation of polygenic risk score analyses: A systematic review.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Feb 2026

Martínez-Minguet Diana, Noel René, G Simón Alberto, Pastor Óscar

Abstract excerpt

PURPOSE: The translation of polygenic risk score (PRS) analyses into clinical practice is gaining momentum; yet, it remains limited by multiple implementation barriers studied across fragmented research lines. This study aims to systematically identify, classify, and synthesize these challenges and the proposed solutions in the literature. METHODS: A systematic literature review is conducted following PRISMA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41384390
DOI: 10.1016/j.gim.2025.101662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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