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Article

Polygenic risk scores in the clinic: Health-system leaders and primary care providers weigh in.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Nov 2025

Trinidad Susan Brown, Fullerton Stephanie M, Cohn Betty, Crosslin David R, Jarvik Gail P

Abstract excerpt

PURPOSE: The fourth phase of the Electronic Medical Records and Genome Network is testing the return of 10 polygenic risk scores (PRS) across multiple clinics. Understanding the perspectives of health-system leaders and frontline clinicians can inform plans for implementation of PRS. METHODS: A total of 15 health-system leaders and 20 primary care providers took part in semistructured interviews. A descriptive...

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Identifiers

PMID: 40916912
DOI: 10.1016/j.gim.2025.101575
PMCID: PMC12457071

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