Article
Predictive role of NUDT15 variants on thiopurine-induced myelotoxicity in Asian inflammatory bowel disease patients.
Pharmacogenomics - 1 Jan 2018
Sutiman Natalia, Chen Sylvia, Ling Khoon Lin, Chuah Sai Wei, Leong Wai Fook, Nadiger Vinayak, Tjai Madeline, Choon Kong Chris San, Schwender Brian John, Chan Webber, Shim Hang Hock, Lim Wee Chian, Khor Chiea Chuen, Cheung Yin Bun, Chowbay Balram
Abstract excerpt
BACKGROUND: Genetic variants of TPMT and NUDT15 have been reported to predict the inter-patient variability in response and toxicity profiles of patients receiving thiopurine therapy. However, the clinical utility of TPMT genotyping in guiding thiopurine doses has been questionable, in part due to underlying differences in the prevalence of TPMT variants in both Caucasian and Asian populations. Several NUDT15...
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