Pharmacogenomic Assessment of Genes Implicated in Thiopurine Metabolism and Toxicity in a UK Cohort of Pediatric Patients With Inflammatory Bowel Disease.

doi:10.1093/ibd/izae126

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Pharmacogenomic Assessment of Genes Implicated in Thiopurine Metabolism and Toxicity in a UK Cohort of Pediatric Patients With Inflammatory Bowel Disease.

Inflammatory bowel diseases - 6 Feb 2025

Coelho Tracy, Cheng Guo, Lewis Sophie, Ashton James J, Barakat Farah, Driscoll Kouros C T, Sholeye-Bolaji Adebola E, Batra Akshay, Afzal Nadeem A, Beattie Robert M, Ennis Sarah

Abstract excerpt

BACKGROUND: Thiopurine drugs are effective treatment options in inflammatory bowel disease and other conditions but discontinued in some patients due to toxicity. METHODS: We investigated thiopurine-induced toxicity in a pediatric inflammatory bowel disease cohort by utilizing exome sequencing data across a panel of 46 genes, including TPMT and NUDT15. RESULTS: The cohort included 487 patients with a median age...

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Topics

Humans
Male
Female
Methyltransferases
Child
Inflammatory Bowel Diseases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Adolescent

Pyrophosphatases

United Kingdom

Cohort Studies

Mercaptopurine

Child, Preschool

Azathioprine

Pharmacogenomic Testing

Pharmacogenetics

Immunosuppressive Agents

Exome Sequencing

Genotype

Source

Open in PubMed

Identifiers

PMID: 39011784
DOI: 10.1093/ibd/izae126

Genes

TPMT
NUDT15
AOX1
DHFR

Provenance

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