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Article

An intronic FTO variant rs16952570 confers protection against thiopurine-induced myelotoxicities in multiethnic Asian IBD patients.

The pharmacogenomics journal - 1 Jun 2020

Chen Sylvia, Tan Wei Zhi, Sutiman Natalia, Lim Cindy, Lee Sze Sing, Leong Wai Fook, Tjai Madeline, Wang Chunyan, Kong Chris San Choon, Chuah Sai Wei, Schwender Brian John, Chan Webber, Shim Hang Hock, Lim Wee Chian, Khor Chiea Chuen, Ling Khoon Lin, Chowbay Balram

Abstract excerpt

Thiopurines are used in the treatment of inflammatory bowel disease (IBD) but remain clinically challenging to manage due to wide interpatient variability in clinical outcomes and adverse events. Apart from genetic variants in thiopurine S-methyltransferase (TPMT) and nudix hydrolase 15 (NUDT15) genes, polymorphisms in FTO alpha-ketoglutarate dependent dioxygenase (FTO) were found predictive of thiopurine-induced...

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PMID: 31813937
DOI: 10.1038/s41397-019-0126-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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