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Article

Probing the Cancer Mutational Landscape of KMT2 Regulatory Subunits.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 15 Apr 2026

Grégoire Sabrina, Chow Sara, Joshi Monika, Zhang Pamela, Ahmad Aws Almir, Janna Ashley, Tremblay Veronique, Muñoz Marcelo, Mer Arvind, Couture Jean-Francois

Abstract excerpt

Members of the Lysine MethylTransferase 2 (KMT2) family are often abnormally expressed and mutated in many cancers. Similarly, several mutations listed in cancer databases map to key functional regions of KMT2 regulatory subunits, such as WD repeat domain 5 (WDR5), Retinoblastoma binding protein 5 (RbBP5), absent-small-homeotic-2-like (ASH2L), and DumPY-30 (DPY-30). In this study, we report the systematic...

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Identifiers

PMID: 41949561
DOI: 10.1096/fj.202504644R
PMCID: PMC13060582

Genes

ASH2L

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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