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Acid-exposed and hypoxic cancer cells do not overlap but are interdependent for unsaturated fatty acid resources

21 Nov 2024

Abstract excerpt

Cancer cells in acidic tumor regions are aggressive and a key therapeutic target, but distinguishing between acid-exposed and hypoxic cells is challenging. Here, we use carbonic anhydrase 9 (CA9) antibodies to mark acidic areas in both hypoxic and respiring tumor areas, along with an HRE-GFP reporter for hypoxia, to isolate distinct cell populations from 3D tumor spheroids. Transcriptomic analysis of...

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PMID: 39572570
DOI: 10.1038/s41467-024-54435-3

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