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Stearoyl coenzyme A desaturase-1: multitasker in cancer, metabolism, and ferroptosis

5 Apr 2023

Abstract excerpt

Cancer progression is a highly balanced process and is maintained by a sequence of finely tuned metabolic pathways. Stearoyl coenzyme A desaturase-1 (SCD1), the fatty enzyme that converts saturated fatty acids into monounsaturated fatty acids, is a critical modulator of the fatty acid metabolic pathway. SCD1 expression is associated with poor prognosis in several cancer types. SCD1 triggers an iron-dependent cell...

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PMID: 37029018
DOI: 10.1016/j.trecan.2023.03.003

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