Article

A cell state specific metabolic vulnerability to GPX4-dependent ferroptosis in glioblastoma

2023-02-23

Abstract excerpt

<h4>SUMMARY</h4> Glioma cells hijack developmental transcriptional programs to control cell state. During neural development, lineage trajectories rely on specialized metabolic pathways. However, the link between tumor cell state and metabolic programs is poorly understood in glioma. Here we uncover a glioma cell state-specific metabolic liability that can be leveraged therapeutically. To model cell state diversi...

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Literature Corpus work: 8e650d47-2201-5505-9e98-f80f39f5e2ee
DOI: 10.1101/2023.02.22.529581

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