Article

SCD inhibition preferentially eradicates AML displaying high de novo fatty acid desaturation and synergizes with chemotherapy

2023-08-05

Abstract excerpt

Identification of specific and therapeutically actionable vulnerabilities in acute myeloid leukaemia (AML) is needed to improve patients’ outcome. These features should be ideally present in many patients independently of mutational background. Here we identify de novo fatty acid (FA) desaturation, specifically stearoyl-CoA desaturase (SCD) inhibition, as a therapeutic vulnerability across multiple AML models in...

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Literature Corpus work: d5dab388-302f-562e-98bd-d0b09a11ddeb
DOI: 10.1101/2023.08.02.551656

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