Article
REDD1 loss reprograms lipid metabolism to drive progression of RAS mutant tumors.
Genes & development - 1 Jun 2020
Qiao Shuxi, Koh Siang-Boon, Vivekanandan Varunika, Salunke Devika, Patra Krushna Chandra, Zaganjor Elma, Ross Kenneth, Mizukami Yusuke, Jeanfavre Sarah, Chen Athena, Mino-Kenudson Mari, Ramaswamy Sridhar, Clish Clary, Haigis Marcia, Bardeesy Nabeel, Ellisen Leif W
Abstract excerpt
Human cancers with activating RAS mutations are typically highly aggressive and treatment-refractory, yet RAS mutation itself is insufficient for tumorigenesis, due in part to profound metabolic stress induced by RAS activation. Here we show that loss of REDD1, a stress-induced metabolic regulator, is sufficient to reprogram lipid metabolism and drive progression of RAS mutant cancers. Redd1 deletion in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.