Article

Cell state-specific metabolic networks govern ferroptosis versus apoptosis in small cell lung cancer

2026-03-31

Abstract excerpt

<h4>SUMMARY</h4> Cellular heterogeneity and plasticity are hallmarks of cancer that contribute to tumor growth and therapy resistance. Here we investigated metabolic heterogeneity in small cell lung cancer (SCLC), an aggressive neuroendocrine (NE) cancer type. Through integrated transcriptomic and metabolomic analyses, we identified a universal dependency on exogenous cysteine/cystine (Cys) across all NE/non-NE S...

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Literature Corpus work: 0083853c-9cd4-5dfd-88c5-4a5af6d4e657
DOI: 10.64898/2026.03.27.714827

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