Article
Gout-associated SNP at the IL1RN-IL1F10 region is associated with altered cytokine production in PBMCs of patients with gout and controls.
Arthritis research & therapy - 20 Nov 2024
Gaal Orsolya I, Leask Megan, Nica Valentin, Cabău Georgiana, Badii Medeea, Hotea Ioana, de Graaf Dennis M, Zhang Zhenhua, Li Yang, Pamfil Cristina, Rednic Simona, Merriman Tony R, Crișan Tania O, Joosten Leo A B
Abstract excerpt
OBJECTIVES: Gout is caused by the response of the innate immune system to monosodium urate (MSU) crystals. A recent gout GWAS identified a signal of genetic association at a locus encompassing IL1RN-IL1F10. Colocalisation analysis using Genotype Tissue Expression Database (GTEx) eQTL data showed that the signal overlaps with genetic control of IL1RN/IL1F10 gene expression. We assess the functional implications of...
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