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Article

Anti-inflammatory activity of an IL-6 missense variant against crystal-induced inflammatory response.

Cytokine - 1 Nov 2026

Li Yang, Leng Jing, Wen Na, Han Huiying, Wang Haozhen, Song Zhijie, Liu Qing, Lu Xiuli, Gao Bing

Abstract excerpt

Interleukin-6 (IL-6) has an important modulator effect on inflammation and immunity and is involved in the progression of nephrolithiasis (kidney stone). However, whether IL-6 genetic variants affect the pathogenesis of kidney stones remains unclear. The present study conducted a combined investigation of candidate gene-driven screening and systematic screening on whole exome sequencing data from 28 patients of...

Read the complete abstract on PubMed

Topics

Humans
Interleukin-6
Polymorphism, Single Nucleotide
Female
Inflammation
Mutation, Missense

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Adult

Kidney Calculi

Calcium Oxalate

Janus Kinase 2

STAT3 Transcription Factor

Nephrolithiasis

Genetic Predisposition to Disease

Molecular Dynamics Simulation

Middle Aged

Receptors, Interleukin-6

Alleles

Source

Identifiers

PMID: 42628418
DOI: 10.1016/j.cyto.2026.157202

Genes

JAK2
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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