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Article

The moderating role of COMT gene rs4680 polymorphism between maladaptive metacognitive beliefs and negative symptoms in patients with schizophrenia.

BMC psychiatry - 20 Nov 2024

Fekih-Romdhane Feten, Kerbage Georges, Hachem Nagham, El Murr Michelle, Haddad Georges, Loch Alexandre Andrade, Abou Khalil Rony, El Hayek Elissar, Hallit Souheil

Abstract excerpt

BACKGROUND: Although the positive association between impairments in metacognitive capacity and negative symptoms in people with schizophrenia spectrum disorders is widely evidenced in the literature, the explaining mechanisms of this association are still less known and poorly understood. This study aims to bridge this knowledge gap by testing the hypothesis that COMT rs4680 variants will act as moderators in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39567927
DOI: 10.1186/s12888-024-06275-0
PMCID: PMC11577635

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