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Article

Effects of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism on executive function in schizophrenia.

Schizophrenia research - 1 May 2007

Roffman Joshua L, Weiss Anthony P, Deckersbach Thilo, Freudenreich Oliver, Henderson David C, Purcell Shaun, Wong Donna H, Halsted Charles H, Goff Donald C

Abstract excerpt

BACKGROUND: The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism has been associated with both overall schizophrenia risk and severity of negative symptoms. This study examined whether schizophrenia patients homozygous for the risk allele (T/T) exhibit greater impairment in executive function, and determined the extent to which MTHFR's effects on negative symptoms underlie this relationship....

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Source

Identifiers

PMID: 17344026
DOI: 10.1016/j.schres.2007.01.003

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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