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Article

Tolcapone-Enhanced Neurocognition in Healthy Adults: Neural Basis and Predictors.

The international journal of neuropsychopharmacology - 1 Dec 2017

Bhakta Savita G, Light Gregory A, Talledo Jo A, Balvaneda Bryan, Hughes Erica, Alvarez Alexis, Rana Brinda K, Young Jared W, Swerdlow Neal R

Abstract excerpt

Background: Failure of procognitive drug trials in schizophrenia may reflect the clinical heterogeneity of schizophrenia, underscoring the need to identify biomarkers of treatment sensitivity. We used an experimental medicine design to test the procognitive effects of a putative procognitive agent, tolcapone, using an electroencephalogram-based cognitive control task in healthy subjects. Methods: Healthy men and...

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Identifiers

PMID: 29020372
DOI: 10.1093/ijnp/pyx074
PMCID: PMC5716101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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