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Uncovering genetic mechanisms of kidney aging through transcriptomics, genomics, and epigenomics

20 Feb 2019

Abstract excerpt

Nephrons scar and involute during aging, increasing the risk of chronic kidney disease. Little is known, however, about genetic mechanisms of kidney aging. We sought to define the signatures of age on the renal transcriptome using 563 human kidneys. The initial discovery analysis of 260 kidney transcriptomes from the TRANScriptome of renaL humAn TissuE Study (TRANSLATE) and the Cancer Genome Atlas identified 37...

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PMID: 30784661
DOI: 10.1016/j.kint.2018.10.029

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