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Evaluation of a genetic risk score based on creatinine-estimated glomerular filtration rate and its association with kidney outcomes.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Oct 2018

Thio Chris H L, van der Most Peter J, Nolte Ilja M, van der Harst Pim, Bültmann Ute, Gansevoort Ron T, Snieder Harold

Abstract excerpt

Background: Meta-analysis of cross-sectional genome-wide association studies (GWAS) on creatinine-estimated glomerular filtration rate (eGFRcrea) identified 53 single-nucleotide polymorphisms (SNPs). These SNP effects can be aggregated into a genetic risk score (GRS) for chronic kidney disease (CKD). To assess its clinical utility, we examined associations with creatinine-estimated kidney outcomes, both...

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PMID: 29294079
DOI: 10.1093/ndt/gfx337

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