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Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline

31 Oct 2020

Abstract excerpt

Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic...

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PMID: 33137338
DOI: 10.1016/j.kint.2020.09.030

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