Article
Whole genome sequence analyses of eGFR in 23,732 people representing multiple ancestries in the NHLBI trans-omics for precision medicine (TOPMed) consortium.
EBioMedicine - 1 Jan 2021
Lin Bridget M, Grinde Kelsey E, Brody Jennifer A, Breeze Charles E, Raffield Laura M, Mychaleckyj Josyf C, Thornton Timothy A, Perry James A, Baier Leslie J, de las Fuentes Lisa, Guo Xiuqing, Heavner Benjamin D, Hanson Robert L, Hung Yi-Jen, Qian Huijun, Hsiung Chao A, Hwang Shih-Jen, Irvin Margaret R, Jain Deepti, Kelly Tanika N, Kobes Sayuko, Lange Leslie, Lash James P, Li Yun, Liu Xiaoming, Mi Xuenan, Musani Solomon K, Papanicolaou George J, Parsa Afshin, Reiner Alex P, Salimi Shabnam, Sheu Wayne H-H, Shuldiner Alan R, Taylor Kent D, Smith Albert V, Smith Jennifer A, Tin Adrienne, Vaidya Dhananjay, Wallace Robert B, Yamamoto Kenichi, Sakaue Saori, Matsuda Koichi, Kamatani Yoichiro, Momozawa Yukihide, Yanek Lisa R, Young Betsi A, Zhao Wei, Okada Yukinori, Abecasis Gonzalo, Psaty Bruce M, Arnett Donna K, Boerwinkle Eric, Cai Jianwen, Yii-Der Chen Ida, Correa Adolfo, Cupples L Adrienne, He Jiang, Kardia Sharon Lr, Kooperberg Charles, Mathias Rasika A, Mitchell Braxton D, Nickerson Deborah A, Turner Steve T, Vasan Ramachandran S, Rotter Jerome I, Levy Daniel, Kramer Holly J, Köttgen Anna, Nhlbi Trans-Omics For Precision Medicine TOPMed Consortium, TOPMed Kidney Working Group, Rich Stephen S, Lin Dan-Yu, Browning Sharon R, Franceschini Nora
Abstract excerpt
BACKGROUND: Genetic factors that influence kidney traits have been understudied for low frequency and ancestry-specific variants. METHODS: We combined whole genome sequencing (WGS) data from 23,732 participants from 10 NHLBI Trans-Omics for Precision Medicine (TOPMed) Program multi-ethnic studies to identify novel loci for estimated glomerular filtration rate (eGFR). Participants included European, African, East...
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