Article

Discovery of genomic and transcriptomic pleiotropy between kidney function and soluble receptor for advanced glycation end-products using correlated meta-analyses: The Long Life Family Study (LLFS)

2023-12-29

Abstract excerpt

<h4>Summary</h4> Patients with chronic kidney disease (CKD) have increased oxidative stress and chronic inflammation, which may escalate the production of advanced glycation end-products (AGE). High soluble receptor for AGE (sRAGE) and low estimated glomerular filtration rate (eGFR) levels are associated with CKD and aging. We evaluated whether eGFR calculated from creatinine and cystatin C share pleiotropic genet...

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Literature Corpus work: 128da75c-f1c6-58c6-bbd9-f97f45595dac
DOI: 10.1101/2023.12.27.23300583

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