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Article

Brain multi-omic Mendelian randomisation to identify novel drug targets for gliomagenesis.

Human molecular genetics - 29 Jan 2025

Thornton Zak A, Andrews Lily J, Zhao Huiling, Zheng Jie, Paternoster Lavinia, Robinson Jamie W, Kurian Kathreena M

Abstract excerpt

BACKGROUND: Genetic variants associated with molecular traits that are also associated with liability to glioma can provide causal evidence for the identification and prioritisation of drug targets. METHODS: We performed comprehensive two-sample Mendelian randomisation (Wald ratio and/or IVW) and colocalisation analyses of molecular traits on glioma. Instrumentable traits (QTLs P < 5 × 10-8) were identified...

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Source

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Identifiers

PMID: 39565278
DOI: 10.1093/hmg/ddae168
PMCID: PMC11780873

Genes

CEP192
D2HGDH
FAIM
HBEGF
SLC8A1

Provenance

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