Article
Genotype-based gene signature of glioma risk.
Neuro-oncology - 1 Jul 2017
Huang Yen-Tsung, Zhang Yi, Wu Zhijin, Michaud Dominique S
Abstract excerpt
BACKGROUND: Glioma accounts for 80% of malignant brain tumors, but its etiologic determinants remain elusive. Despite genetic susceptibility loci identified by genome-wide association study (GWAS), the agnostic approach leaves open the possibility that other susceptibility genes remain to be discovered. Here we conduct a gene-centric integrative GWAS (iGWAS) of glioma risk that combines transcriptomics and...
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