Article
Using germline variants to estimate glioma and subtype risks.
Neuro-oncology - 18 Mar 2019
Eckel-Passow Jeanette E, Decker Paul A, Kosel Matt L, Kollmeyer Thomas M, Molinaro Annette M, Rice Terri, Caron Alissa A, Drucker Kristen L, Praska Corinne E, Pekmezci Melike, Hansen Helen M, McCoy Lucie S, Bracci Paige M, Erickson Bradley J, Lucchinetti Claudia F, Wiemels Joseph L, Wiencke John K, Bondy Melissa L, Melin Beatrice, Burns Terry C, Giannini Caterina, Lachance Daniel H, Wrensch Margaret R, Jenkins Robert B
Abstract excerpt
BACKGROUND: Twenty-five single nucleotide polymorphisms (SNPs) are associated with adult diffuse glioma risk. We hypothesized that the inclusion of these 25 SNPs with age at diagnosis and sex could estimate risk of glioma as well as identify glioma subtypes. METHODS: Case-control design and multinomial logistic regression were used to develop models to estimate the risk of glioma development while accounting for...
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