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Article

Transcriptome-wide Mendelian randomization study prioritising novel tissue-dependent genes for glioma susceptibility.

Scientific reports - 27 Jan 2021

Robinson Jamie W, Martin Richard M, Tsavachidis Spiridon, Howell Amy E, Relton Caroline L, Armstrong Georgina N, Bondy Melissa, Zheng Jie, Kurian Kathreena M

Abstract excerpt

Genome-wide association studies (GWAS) have discovered 27 loci associated with glioma risk. Whether these loci are causally implicated in glioma risk, and how risk differs across tissues, has yet to be systematically explored. We integrated multi-tissue expression quantitative trait loci (eQTLs) and glioma GWAS data using a combined Mendelian randomisation (MR) and colocalisation approach. We investigated how...

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Genetic Predisposition to Disease
Genome-Wide Association Study
Glioma
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Quantitative Trait Loci

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Identifiers

PMID: 33504897
DOI: 10.1038/s41598-021-82169-5
PMCID: PMC7840943

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